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KMID : 1011920210220010009
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International Journal of Arrhythmia
2021 Volume.22 No. 1 p.9 ~ p.9
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Factors predicting poor anticoagulant control on warfarin in a Thai population with non-valvular atrial fibrillation (NVAF): the ACAChE score
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Lertsanguansinchai Piyoros
Huntrakul Anurut
Rungpradubvong Voravut
Chokesuwattanaskul Ronpichai
Prechawat Somchai
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Abstract
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Background: In many low- to middle-income countries in Asia, patients with NVAF usually received warfarin for thromboembolic prevention due to cost-effectiveness. The SAMe-TT2R2 score has been proposed to predict TTR in NVAF patients. However, the SAMe-TT2R2 score has not been much validated in Asian population. Interestingly, it may overestimate patients who had TTR?
Objectives: To determine the factors predicting poor anticoagulant control on warfarin, create new scoring system, and compare with the SAMe-TT2R2 score in a Thai population with NVAF.
Methods: This is a retrospective study in a tertiary care hospital. We enrolled NVAF patients who received warfarin from January 2014 to December 2018. TTR was calculated based on Rosendaal method. Multiple logistic regression and AUC-ROC curve were used for analysis.
Results: A total of 864 patients were enrolled with mean age of 73.6?±?11.58 years. The mean TTR was 48.1?±?25.2%. Using multivariate regression analysis, the predictive factors for TTR?
Conclusion: In Thai NVAF patients, the ACAChE score (antiplatelet use, chronic kidney disease (GFR?
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KEYWORD
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Atrial fibrillation, Warfarin, Time in therapeutic range, Same-TT2R2, TTR
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